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ACROBiosystems Biotinylated Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His, Avitag™&Tag Free
Biotinylated Protein
Marke: ACROBiosystems IT8-H82W5-25ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.
Biotinylated Human ITGAV&ITGB8 Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of ITGAV and ITGB8, has a calculated MW of 114.7 kDa (ITGAV) and 76.5 kDa (ITGB8). Subunit ITGAV is fused with an acidic tail at the C-terminus and followedSpezifikation
| NP_002201.1 (ITGAV) and NP_002205.1 (ITGB8) | |
| 25 μg | |
| Phe 31 - Val 992 (ITGAV) and Glu 43 - Arg 684 (ITGB8) | |
| Integrin alpha V beta 8,ITGAVandITGB8 | |
| Precision Avi | |
| His Tag and Avi Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 114.7 kDa (ITGAV) and 76.5 kDa (ITGB8) | |
| Biotinylated Human ITGAV&ITGB8; Heterodimer Protein, His,AviTag&Tag; Free (IT8-H82W5) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) and Glu 43 - Arg 684 (ITGB8) (Accession # NP_002201.1 (ITGAV) and NP_002205.1 (ITGB8)). | |
| -20°C | |
| Integrin alpha V beta 8 | |
| Human | |
| 50 mM Tris, 150 mM NaCl, pH8.0 | |
| HEK293 | |
| MABSol™ Biotin Labeled Proteins |