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ACROBiosystems Human CD20 / MS4A1 Full Length Protein, His Tag (Nanodisc) (HEK293)
Marke: ACROBiosystems CD0-H52H1-500ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
B-lymphocyte antigen CD20 is also known as B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1 and MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells. It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. The protein has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that it acts as a calcium channel in the cell membrane. CD20 / MS4A1 is the target of the monoclonal antibodies (mAb) rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen.
Nanodiscs are a new class of model membranes that are being used to solubilize and study a range of integral membrane proteins (mp,full length CD20) and membrane-associated proteins. The Nanodisc bilayer is bounded by a membrane scaffold protein (MSP1D1)Spezifikation
| NP_068769.2 | |
| 35.2 kDa | |
| 500 µg | |
| Met 1 - Pro 297 | |
| MS4A1,CD20,MS4A-1 | |
| Unconjugated | |
| 20 mM HEPES, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Human |
| Liquid | |
| >85% as determined by SDS-PAGE | |
| Human CD20 Full Length, His Tag (CD0-H52H1) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Pro 297 (Accession # P11836-1). | |
| -70°C | |
| CD20 | |
| His Tag | |
| Less than 1.0 EU / µg by the LAL method. | |
| Bio-Markers and CD Antigens |