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ACROBiosystems Human GUCY2C / Guanylyl cyclase C Protein, Fc Tag
Marke: ACROBiosystems GUC-H5257-1mg
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.5 kDa. The protein migrates as 80-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_004954.2 | |
| 1 mg | |
| Ser 24 - Gln 430 | |
| GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 72.5 kDa | |
| Human GUCY2C, Fc Tag (GUC-H5257) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1). | |
| -20°C | |
| GUCY2C | |
| Human | |
| 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |