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ACROBiosystems Mouse GUCY2C / Guanylyl cyclase C Protein, Fc Tag

Marke:  ACROBiosystems GUC-M5254-1mg

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 17106361

  • 2330.32 € / 1 Milligramm

Voraussichtliches Versanddatum: 01-10-2021

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Beschreibung

Beschreibung

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Mouse GUCY2C, Fc Tag (GUC-M5254) is expressed from human 293 cells (HEK293). It contains AA Val 20 - Met 433 (Accession # Q3UWA6-1).
-20°C
GUCY2C
Fc Tag
HEK293
Mouse
73.5 kDa
1 mg
Val 20 - Met 433
GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
Unconjugated
PBS, pH7.4
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate