missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Human M-CSF R / CSF1R / CD115 Protein, Mouse IgG2a Fc Tag

MALS verified

Marke:  ACROBiosystems CSR-H5255-100ug

Weitere Details : Netto-Gewicht : 0.00010kg

 Weitere Artikel aus diesem Sortiment

Artikelnummer. 17126261

  • 359.89 € / 100 Mikrogramm
Verfügbar ab: 09-04-2024
Sie sich ein, um den Lagerbestand zu sehen

Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!


Beschreibung

Beschreibung

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeIII subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 81.4 kDa. The protein migrates as 105-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_005202.2
100 μg
Ile 20 - Glu 512
CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
Unconjugated
Mouse IgG Fc Tag
Less than 0.1 EU / μg by the LAL method.
Powder
>90% as determined by SDS-PAGE
81.4 kDa
Human M-CSF R, Mouse IgG2a Fc Tag (MALS verified) (CSR-H5255) is expressed from human 293 cells (HEK293). It contains AA Ile 20 - Glu 512 (Accession # P07333-1).
-20°C
M-CSF R
Human
PBS, pH7.4
HEK293
Bio-Markers and CD Antigens
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote