missing translation for 'onlineSavingsMsg'
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ACROBiosystems Human PCSK9 Propeptide & Rabbit Mature PCSK9 (154-686) Protein, His Tag
Marke: ACROBiosystems PC9-R52H5-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non covalent interactions and with a calculatedSpezifikation
| NP_777596.2 and N/A | |
| 100 µg | |
| Gln 31 - Gln 152 and Ser 154 - Ala 686 | |
| PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / µg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 13.8 kDa and 58.0 kDa | |
| Human PCSK9 Propeptide and Rabbit Mature PCSK9 (154-686), His Tag (PC9-R52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gln 152 and Ser 154 - Ala 686 (Accession # Q8NBP7-1 (Human) and A0A5F9DJY7-1 (Rabbit)). | |
| -20°C | |
| PCSK9 | |
| Rabbit | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |