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ACROBiosystems Cynomolgus GUCY2C / Guanylyl cyclase C Protein, Fc Tag
Marke: ACROBiosystems GUC-C5255-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.6 kDa. The protein migrates as 95-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| XP_005570270.1 | |
| 100 μg | |
| Ser 24 - Gln 430 | |
| GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 72.6 kDa | |
| Cynomolgus GUCY2C, Fc Tag (GUC-C5255) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # XP_005570270.1). | |
| -20°C | |
| GUCY2C | |
| Cynomolgus Monkey | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |