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ACROBiosystems Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, Fc, Avitag™

Biotinylated Protein

Marke:  ACROBiosystems GUC-H82F8-200ug

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 17156351

  • 1847.47 € / 200 Mikrogramm
Verfügbar ab: 08-04-2024
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Beschreibung

Beschreibung

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 74.1 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_004954.2
200 μg
Ser 24 - Gln 430
GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
Precision Avi
Fc Tag and Avi Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>90% as determined by SDS-PAGE
74.1 kDa
Biotinylated Human GUCY2C, Fc,Avitag (GUC-H82F8) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1).
-20°C
GUCY2C
Human
PBS, pH7.4
HEK293
MABSol™ Biotin Labeled Proteins
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote