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ACROBiosystems Human Syndecan-1 Protein, Fc Tag

Marke:  ACROBiosystems SY1-H5253-100ug

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 17166781

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Beschreibung

Beschreibung

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.3 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human Syndecan-1, Fc Tag (SY1-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Gly 254 (Accession # P18827-1).
-20°C
Syndecan-1
Fc Tag
HEK293
Human
50.3 kDa
100 µg
Gln 23 - Gly 254
SDC1,Syndecan-1,CD138,SYND1,SDC
Unconjugated
PBS, pH7.4
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate