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14-3-3 Mouse, Unlabeled, Clone: 12/14-3-3, BD
Mouse Monoclonal Antibody
N.V.
Spezifikation
| Antigen | 14-3-3 |
|---|---|
| Klon | 12/14-3-3 |
| Konzentration | 250μg/mL |
| Anwendungen | Immunofluorescence, Immunohistochemistry, Western Blot |
| Klassifikation | Monoclonal |
Beschreibung
The family of 14-3-3 proteins has been implicated in numerous cellular processes such as neurotransmission, phospholipase activity, and calcium signaling. The 14-3-3 protein can associate with several proteins involved in cell proliferation, such as Raf-1, Bcr-Abl, middle T antigen, and CDC25 phosphatase. It appears that 14-3-3 proteins enhance the kinase activity of the Raf proto-oncogene equally as well as Ras, thus, implicating 14-3-3 proteins in the Raf/Ras/Map kinase signaling pathway. However, in spite of 14-3-3 direct association with the CDC25 phosphatase, this interaction does not increase the phosphatase activity. It has been reported that this antibody detects 14-3-3 subunits β, γ, η, Θ, and ζ , but not ε nor σ.
Spezifikation
| 14-3-3 | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Canine, Chicken, Frog, Human, Mouse, Rat | |
| Human 14-3-3 | |
| Primary | |
| Store undiluted at -20°C. |
| 12/14-3-3 | |
| Immunofluorescence, Immunohistochemistry, Western Blot | |
| Unconjugated | |
| RUO | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgM | |
| Affinity Purified |
For Research Use Only.