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beta-2 Microglobulin Monoclonal Antibody (B2M-01), FITC, Invitrogen™
Mouse Monoclonal Antibody
Marke: Invitrogen A15737
Weitere Details : Netto-Gewicht : 0.00280kg
Beschreibung
Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predomitly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.Spezifikation
beta-2 Microglobulin | |
Monoclonal | |
1 mg/mL | |
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4 | |
P61769 | |
B2M | |
human beta2-microglobulin. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2a |
Flow Cytometry | |
B2M-01 | |
FITC | |
B2M | |
B2-microglobulin, B2M, CDABP0092, HDCMA22P, beta chain MHC class I molecules, MHC Class 1 beta | |
Mouse | |
Purified | |
RUO | |
567 | |
4° C | |
Liquid |