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Caspase 1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Marke:  Invitrogen PA517570

Weitere Details : Netto-Gewicht : 0.01000kg

Artikelnummer. 11502470

  • 338.00 € / 100 Mikroliter


Voraussichtlicher Liefertermin 07-08-2019
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Beschreibung

Beschreibung

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.
Spezifikation

Spezifikation

Caspase 1
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P29466
CASP-1; CASP1 nirs variant 1; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase); caspase-1; interleukin 1-B converting enzyme; interleukin 1-beta convertase; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme
Rabbit
IgG
100 μL
-20°C
Primary
834
Western Blot
Unconjugated
CASP1
Liquid
CASP1
Synthetic peptide corresponding to residues within the p20 subunit of human caspase-1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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