Caspase 3 Rabbit anti-Ferret, Human, Mouse, Rat, Polyclonal, Invitrogen™

Beschreibung

PA1-26426 detects active Caspase 3 from human, mouse, ferret, and rat samples. PA1-26426 has been successfully used in immunohistochemistry (paraffin and frozen), Immunofluorescence, and Western blot procedures. Positive controls of rat brain or foetus, or mouse foetus suggested. Store at 4°C short term. For extended storage, aliquot and store at -20°C or below. Avoid freeze/thaw cycles.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predomit caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer′s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.