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Caspase 8 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Marke:  Invitrogen PA127990

Weitere Details : Netto-Gewicht : 0.01000kg

Artikelnummer. 11551323

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Beschreibung

Beschreibung

PA1-27990 detects Caspase 8 from human samples. PA1-27990 has been successfully used in Western blot applications. The PA1-27990 immunogen is: Synthetic peptide: K-GDNYQKGIPVETD conjugated to KLH, corresponding to amino acids 362-374 (with a N-terminal added lysine) of Human Caspase 8a (MACH alpha 1). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases play a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD. Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis. In addition, Caspase 8 also reacts with Jurkat cells and Tonsil. Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family. Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
Spezifikation

Spezifikation

Caspase 8
Polyclonal
CASP8
Caspase-8, FLICE, MACH, Mch5
Rabbit
IgG fraction
RUO
841
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
Unconjugated
Q14790
CASP8
synthetic peptide K-GDNYQKGIPVETD conjugated to KLH, corresponding to amino acids 362-374 (with a N-terminal added lysine) of Human Caspase 8a (MACH alpha 1).
100 μL
Primary
Human
Antibody
IgG
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote