missing translation for 'onlineSavingsMsg'
Learn More

Cathepsin D Mouse anti-Human, Mouse, Rat, Clone: AF4G5, Invitrogen™

Mouse Monoclonal Antibody

Marke:  Invitrogen MA517236

Weitere Details : Netto-Gewicht : 0.01000kg

Artikelnummer. 15398210

Dieser Artikel ist im Moment nicht verfügbar oder wird nicht mehr hergestellt.
Schauen Sie bitte auf unsere Produktseite nach möglichen Alternativen


Beschreibung

Beschreibung

A suggested positive control for this product is SK-BR3 cells.

Cathepsin D (CatD) is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins apoptosis and autophagy. Human CatD is synthesized on the endoplasmic reticulum as a pre-pro-enzyme. Preprocathepsin D (412aa) is cleaved and glycosylated to form an inactive procathepsin D (392aa) and then further cleaved to generate an active intermediate (348aa) single-chain molecule. The active intermediate is further processed into mature two chain form of cathepsin D, this processing step is carried out by cathepsin B or L. The two-chain form consists of an amino terminal light chain and a carboxyl-terminal heavy chain. Additionally, several more amino acids are removed from the carboxyl terminus of the heavy chain. Procathepsin D (pCD), secreted from cancer cells, acts as a mitogen on both cancer and stromal cells and stimulates their proinvasive and pro-metastatic properties.
Spezifikation

Spezifikation

Cathepsin D
Monoclonal
1 mg/mL
HEPES with 0.01% BSA, 0.15M NaCl, 50% glycerol and 0.03% sodium azide
P07339, P18242, P24268
CTSD
Recombit human protein purified from E.coli (His-Cathepsin D)
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG1
Immunocytochemistry, Immunofluorescence, Western Blot
AF4G5
Unconjugated
CTSD
OTTHUMP00000196039; OTTHUMP00000198692; ceroid-lipofuscinosis; neuronal 10; lysosomal aspartyl peptidase; lysosomal aspartyl protease
Mouse
Protein G
RUO
13033, 1509, 171293
-20°C
Liquid
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote