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Caveolin 1 Mouse, Unlabeled, Clone: 2297, BD
Mouse Monoclonal Antibody
330.00 € - 545.00 €
Specifications
Antigen | Caveolin 1 |
---|---|
Klon | 2297 |
Konzentration | 250μg/mL |
Anwendungen | Western Blot |
Klassifikation | Monoclonal |
Product Code | Brand | Menge | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Menge | Price | Quantity & Availability | |||||
15895439
|
BD Biosciences
610406 |
50 μg |
330.00 €
1 Set |
Verfügbar ab: 15-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
15805449
|
BD Biosciences
610407 |
150 μg |
545.00 €
1 Set |
Verfügbar ab: 15-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Description
Identified as a tyrosine phosphorylated protein in Rous sarcoma virus-transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed. Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-Golgi network (TGN) and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins. Caveolin-1 can generate two forms, α and β, due to alternate splicing of the mRNA. The α isoform has been reported to be observed at 24kDa and the β isoform at 21kDa. Caveolin-1 forms large lipid-binding homo-oligomers which are believed to play a role in caveolae formation. It may also function as a scaffolding protein which concentrates andorganizes signaling molecules, a role supported by the fact that caveolin-1 interacts directly with inactive Ras and G-protein α subunits.
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Specifications
Caveolin 1 | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 | |
Affinity Purified |
2297 | |
Western Blot | |
Unconjugated | |
RUO | |
Canine, Chicken, Human, Mouse, Rat | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.