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CD138 Rat anti-Mouse, APC, Clone: 281-2, BD

Rat Monoclonal Antibody

Marke:  BD Biosciences 561705

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15801259

  • 132.00 € / 1 Stück

Verfügbar ab
14-10-2020

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Beschreibung

Beschreibung

The 281-2 antibody reacts with the core protein of CD138 (Syndecan-1), a cell-surface, integral membrane heparan sulfate- and chondroitin sulfate-containing proteoglycan that binds to interstitial extracellular matrix molecules. Syndecan-1 is predominantly expressed on epithelial cells, where its expression correlates with normal epithelial organization. It is also expressed on B lymphocytes at specific stages during their differentiation: precursor B cells in the bone marrow and antibody-secreting cells, including plasma cells, but not mature peripheral B cells. It is thus implicated in mediating B cell-matrix interactions. CD138 expression is also regulated during embryonic development, and the molecule shows a tissue- specific structural polymorphism resulting from different post-translational modifications. The 281-2 antibody may be used to detect the differently glycosylated forms, because it reacts with the core protein. Furthermore, the mAb detects the Syndecan-1 ectodomain which is cleaved from cell surfaces by a metalloproteinase.

Flow Cytometry

Spezifikation

Spezifikation

CD138
281-2
APC
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2a, κ
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
SYND1; Syndecan-1; syn-1; Sdc1; Sstn; synstatin
Affinity Purified
NAMRU mouse mammary gland epithelial cell line NMuMG
25μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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For Research Use Only.