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CD253 Mouse anti-Human, PE, Clone: RIK-2, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 561784

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15891329

  • 185.82 € / 1 Stück
Verfügbar ab: 23-12-2022
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Beschreibung

Beschreibung

The RIK-2 monoclonal antibody specifically binds to CD253 which is also known as TRAIL (TNF-Related Apoptosis-Inducing Ligand) and Apo2 ligand (APO-2L). CD253 is a member of the Tumor Necrosis Factor Superfamily and is encoded by the TNFSF10 gene. CD253 is a type II membrane protein that may be expressed as a full-length, cell surface associated protein as well as in a soluble form. Both surface and soluble forms of TRAIL rapidly induce apoptosis by a wide range of cell lines but not by normal cells. TRAIL is expressed by activated T cells, NK cells, dendritic cells, monocytes and by a variety of non-lymphoid cells. TRAIL can bind to and exert apoptosis through DR4 (TRAIL-R1) and DR5 (TRAIL-R2) receptors. It can also bind to decoy receptors, including DcR1/TRID/TRAIL-R3 and DcR2/TRUNDD/TRAIL-R4, and possibly OPG/TNFRSF11B, which may serve to regulate TRAIL activity. TRAIL has been shown to be involved in T cell-mediated cytotoxicity, however its mechanism of action remains to be fully elucidated. The RIK-2 clone was selected based on its ability to block TRAIL-mediated cytotoxic activity.

Spezifikation

Spezifikation

CD253
Monoclonal
0.2mg/mL
TNFSF10; TRAIL; APO-2L; TL2
Mouse
Affinity Purified
RUO
Human
IgG1
Flow Cytometry
RIK-2
PE
Aqueous buffered solution containing ≤0.09% sodium azide.
Human TRAIL Transfected Cell Line
25 μg
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Dokumentation

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For Research Use Only.