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CD3 Mouse anti-Human, BB515, Clone: UCHT1, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 564465

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15803669

  • 315.00 € / 1 Stück

Verfügbar ab
16-10-2020

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Beschreibung

Beschreibung

The UCHT1 monoclonal antibody specifically binds to the human CD3 ε -chain, a 20-kDa subunit of the CD3/T cell antigen receptor complex. CD3 ε is expressed on 70-80% of normal human peripheral blood lymphocytes and 60-85% of thymocytes. Studies from the HLDA Workshop show that this antibody is mitogenic for CD3 ε -positive cells when used in conjunction with costimulatory agents such as pokeweed mitogen or anti-CD28 antibody. CD3 plays a central role in signal transduction during antigen recognition. The UCHT1 antibody stains both surface and intracellular CD3 ε unlike the other CD3 clone, HIT3a, that stains only extracellular CD3 ε .

The antibody was conjugated to BD Horizon™ BB515 which was developed exclusively by BD Biosciences. With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (e.g. 530/30-nm filter). This dye provides a much brighter alternative to FITC with less spillover into the PE detector.

Spezifikation

Spezifikation

CD3
UCHT1
CD3e; CD3E; T3E; TCRE; T-cell surface antigen T3/Leu-4 epsilon
Affinity Purified
Human infant thymocytes and peripheral blood lymphocytes from a Sézary Syndrome donor
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
BB515
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
IgG1, κ
RUO
Primary
Human
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For Research Use Only.