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CD40 Rat anti-Mouse, FITC, Clone: 3/23, BD

Rat Monoclonal Antibody

Marke:  BD Biosciences 561845

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15801399

  • 162.00 € / 1 Stück

Verfügbar ab
16-10-2020

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Beschreibung

Beschreibung

The 3/23 clone monoclonal antibody specifically binds to CD40, a 40-50 kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells. CD40 has been reported to be transiently expressed on activated CD4+ and CD8+ T cells and in some mouse strains, the 3/23 mAb has been reported to react with 5-10% of T lymphocytes in adult mouse, but not neonatal, spleen. CD40 plays a key role in B-cell growth and differentiation where interactions of CD40 with its ligand, CD154, are involved in the initiation, effector, and memory stages of cell-mediated immune responses. In addition, CD40 has been reported to be involved with the triggering of NK cells and NK-T cells. Ligation of CD40 with the 3/23 antibody has been reported to induce splenic B cells to express the costimulatory molecule CD86 (B7-2). In addition, although the 3/23 antibody by itself is a weak B-cell mitogen, it has been reported to synergize markedly with mitogenic anti-IgM, anti-IgD mAb or IL-4 to promote B-cell proliferation.

Spezifikation

Spezifikation

CD40
3/23
FITC
Affinity Purified
Mouse CD40 Recombinant Protein
0.1mg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2a, κ
RUO
Primary
Murine
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