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CD5 Rat anti-Mouse, APC, Clone: 53-7.3, BD
Rat Monoclonal Antibody
Marke: BD Biosciences 561895
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
The 53-7.3 monoclonal antibody specifically binds to a monomorphic epitope of CD5, a member of the scavenger receptor cysteine-rich protein superfamily and the major ligand of CD72, found on thymocytes, T lymphocytes, thymic NKT cells, and a subset of B lymphocytes, but not on NK cells or splenic NKT cells. The level of surface CD5 expression is developmentally regulated in the thymus, starting with low levels on CD4-CD8- thymocytes and increasing as they mature to CD4+CD8+ then CD4+CD8- or CD4-CD8+ thymocytes. Relatively high levels are maintained on peripheral T lymphocytes. The level of CD5 antigen detected on T helper cells has been reported to be somewhat higher than that on T cytotoxic/suppressor and B cells. Few, if any, intestinal intraepithelial lymphocytes bearing the γδ T-cell receptor express CD5. Phenotypic, anatomical, functional, developmental, and pathogenic characteristics of peripheral CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. The frequency of these CD5+ B cells has been reported to show strain-dependent variation. An additional population of CD5+ B lymphocytes resides in the thymus, where it matures from intrathymic B-cell progenitors. It has been proposed that CD5 is a costimulatory molecule which mediates interactions of cells in the immune system and negatively regulates signal transduction mediated by the T-cell receptor and B-cell receptor.
Spezifikation
| CD5 | |
| Monoclonal | |
| 0.2mg/mL | |
| Lymphocyte antigen 1; Cd5; Ly-12; Ly-A; Lyt-1 | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgG2a κ |
| Flow Cytometry | |
| 53-7.3 | |
| APC | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse Thymus / Spleen | |
| 25 μg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
For Research Use Only.