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CD54 Hamster anti-Mouse, FITC, Clone: 3E2, BD

Hamster Monoclonal Antibody

Marke:  BD Biosciences 553252

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15897098

  • 451.44 € / 1 Stück
Verfügbar ab: 23-12-2022
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Beschreibung

Beschreibung

The 3E2 antibody reacts with CD54 (ICAM-1), a 95-kDa member of the Ig superfamily found on lymphocytes, vascular endothelium, high endothelial venules, epithelial cells, macrophages, and dendritic cells. ICAM-1 is a ligand for LFA1 (CD11a/CD18) and Mac-1 (CD11b/CD18). Its expression is upregulated upon stimulation by inflammatory mediators such as cytokines and LPS. Studies with mouse Icam1-transfected antigen-presenting cells, with CD54-blocking antibodies, and in CD54-deficient mice indicate that CD54 participates in inflammatory reactions and antigen-specific immune responses. In addition, there is evidence that CD54 is a receptor involved in MHC-non-restricted responses to weakly immunogenic tumor cells. The 3E2 antibody has been reported to block in vitro and in vivo intracellular adhesion events involved in immune responses.

Spezifikation

Spezifikation

CD54
Monoclonal
0.5mg/mL
ICAM-1; Icam1; Intercellular adhesion molecule 1; Ly-47; MALA-2; MyD10
Hamster
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
3.00E+02
FITC
Aqueous buffered solution containing ≤0.09% sodium azide.
Not reported
0.5 mg
Immunology
Mouse
IgG1 κ
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