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CD8 Mouse anti-Human, APC-Cy7, Clone: SK1, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 561945

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15801499

  • 185.00 € / 1 Stück

Verfügbar ab
14-10-2020

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Beschreibung

Beschreibung

The SK1 monoclonal antibody specifically binds to CD8 alpha (CD8α). CD8α is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD8α is expressed by the majority of thymocytes, by subpopulations of αβ T cells and γδ T cells and by some NK cells. Cell surface CD8α is expressed either as a disulfide-linked homodimer (CD8αα) or as a heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8β). CD8-positive αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express CD8αα homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a co-receptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling.

Spezifikation

Spezifikation

CD8
SK1
CD8α; CD8A; CD8 alpha; Leu2a; MAL; T8; p32
Affinity Purified
Human Peripheral Blood T Cells
25 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
APC-Cyanine7
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG1, κ
RUO
Primary
Baboon, Cynomolgus, Human, Rhesus
Videos
Dokumentation

For Research Use Only.