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CD8a Rat anti-Mouse, Biotin, Clone: 53-6.7, BD

Rat Monoclonal Antibody

143.00 € - 545.00 €

Spezifikation

Antigen CD8a
Klon 53-6.7
Konzentration 0.5mg/mL
Anwendungen Flow Cytometry
Klassifikation Monoclonal
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15886938
Unterlagen ansehen Aktionsdetails
BD Biosciences
553028
0.1 mg
143.00 €
1 Stück
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Verfügbar ab: 23-04-2024
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15896938
Unterlagen ansehen Aktionsdetails
BD Biosciences
553029
0.5 mg
545.00 €
1 Stück
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 23-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!
Beschreibung

Beschreibung

The 53-6.7 antibody has been reported to react with the 38 kDa α and 34 kDa α' chains of the CD8 differentiation antigen (Ly-2 or Lyt-2) of all mouse strains tested. The CD8 α and α' chains (CD8a) form heterodimers with the CD8 β chain (CD8b, Ly-3, or Lyt-3) on the surface of most thymocytes. A subpopulation of mature T lymphocytes (i.e., MHC class I-restricted T cells, including most T suppressor/cytotoxic cells) expresses almost exclusively the CD8 αβ heterodimer (the α' chain is absent). Subsets of γδ TCR-bearing T cells, intestinal intrapithelial lymphocytes, and dendritic cells express CD8a without CD8b. It has been suggested that the expression of the CD8a/CD8b heterodimer is restricted to T lymphocytes which matured in the thymus or in an extrathymic environment that had been influenced by thymus-initiated neuroendocrine signals. CD8 is an antigen coreceptor on the T-cell surface which interacts with MHC class I molecules on antigen-presenting cells or epithelial cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase lck (p56 [lck]). The CD8 α and α' chains arise from alternatively spliced messengers of a single CD8a gene. The longer α form associates with p56 [lck] via a CXCP motif in its cytoplasmic domain, which it shares with CD4, but not with CD8b. The truncated α' chain is unable to associate with p56 [lck], and it may function to attenuate the CD8-mediated costimulatory signal during intrathymic T-cell maturation. In vivo and in vitro treatment with 53-6.7 mAb has reportedly been effective at depleting CD8+ peripheral T lymphocytes. The 53-6.7 antibody has also been reported to cross-reaact with CD8 α- and α'-like polypeptides on subsets of thymic and peripheral lymphocytes in the Egyptian toad,
Bufo regularis. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Rat
Clone: 53-6.7
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: Mouse Thymus / Spleen

Cell Separation, Flow Cytometry

Spezifikation

Spezifikation

CD8a
0.5mg/mL
Monoclonal
Rat
Immunology
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG2a κ
Affinity Purified
Cd8a; CD8 alpha chain; Ly-2; Lyt2; Lyt-2; Ly-35; Ly-B
53-6.7
Flow Cytometry
Biotin
RUO
Mouse
Mouse Thymus / Spleen
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Dokumentation

Dokumentation

Produktzertifizierungen

For Research Use Only.