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eIF-4E Mouse, Unlabeled, Clone: 87, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 610270

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15895369

  • 660.06 € / 1 Set
Verfügbar ab: 19-12-2022
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Beschreibung

Beschreibung

The eukaryotic translation initiation factor 4E (eIF-4E) is a 25kDa phosphoprotein that specifically binds to the 7-methylguanosine-containing cap of mRNA. eIF-4E is the rate-limiting component for the initiation of cap-dependent translation by the eIF-4E translation initiation complex. This complex promotes the unwinding of secondary structure at the 5′ untranslated region of mRNA, which is necessary to expose and locate the AUG-initiation codon. Phosphorylation of eIF-4E on Ser-209 occurs after serum treatment in CHO cells, and may regulate its function. Overexpression of eIF-4E can lead to increased cell proliferation, transformation, and tumorigenesis in nude mice. The overexpression of a Ala-53 variant of eIF-4E cannot evoke these changes, suggesting that Ser-53 on eIF-4E participates in the transfer of mRNA to the 48S initiation complexes. In cooperation with nuclear oncogenes such as c-myc or E1A, eIF-4E transforms primary cells. Other studies have demonstrated that overexpression of eIF-4E causes activation of Ras and leads to a transformed phenotype. Subsequent overexpression of GAP then causes reversion of this phenotype. The mechanism by which eIF-4E plays a role in transformation is not clear, but it is postulated that high levels of eIF-4E may lead to the translation of mRNAs that are normally translationally repressed.

Host Species: Mouse
Clone: 87
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Rabbit eIF-4E aa. 1-217

Immunofluorescence, Immunoprecipitation

Spezifikation

Spezifikation

eIF-4E
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
and ≤0.09% sodium azide., glycerol, Aqueous buffered solution containing BSA
150 μg
Cell Biology
Rat, Mouse, Human, Frog, Chicken, Canine
IgG1
Western Blot
87
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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Sicherheitsdatenblatt (SDS)
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Sonderangebote

Sonderangebote

For Research Use Only.