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HAX-1 Mouse, Unlabeled, Clone: 52, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 610825

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15885659

  • 647.52 € / 1 Set
Verfügbar ab: 02-01-2023
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Beschreibung

Beschreibung

Cell-cell interactions in the immune system, mediated by membrane-bound antigen receptors, trigger a cascade of signaling mechanisms collectively known as the T-cell response. Upon antigen binding, cellular tyrosine kinases are activated resulting in the phosphorylation of HS1 or Lck-binding protein 1 (LckBP1), which is involved in thymic negative selection. HS1 is one of the earliest intracellular proteins to be tyrosine phosphorylated in response to antigen-receptor cross-linking in T cells. HAX-1 (HS1-associated protein X-1) is a 35kDa protein found associated with HS1 by co-immunoprecipitation assays and the two-hybrid system. HAX-1 is ubiquitously expressed and localized in the mitochondria, endoplasmic reticulum, and the nuclear envelope. The HS1-HAX-1 complex may be critical for signal transduction pathways initiated by antigen presentation to T cells.

Immunofluorescence, Immunoprecipitation, Western Blotting

Spezifikation

Spezifikation

HAX-1
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human HAX-1 aa. 10-148
150 μg
Cell Biology
Rat, Mouse, Human
IgG1
Western Blot
52
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.