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IL-21 Polyclonal Antibody, Invitrogen™
Goat Polyclonal Antibody
Marke: Invitrogen PA121355
Weitere Details : CAS : 69-74-9 Netto-Gewicht : 0.01000kg
Beschreibung
PA1-21355 detects IL-21 in Mouse samples. PA1-21355 has been successfully used in ELISA and Immunohistochemistry (paraffin) procedures. PA1-21355 immunogen corresponds to Synthetic peptide of Mouse IL21 N terminal amino acids 32-61 [CRHLIDIVEQLKIYENDLDPELLSAPQDVK].
IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintece by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.Spezifikation
IL-21 | |
Polyclonal | |
Unconjugated | |
Q9ES17 | |
IL21 | |
Synthetic peptide of Mouse IL21 N terminal amino acids 32-61 [CRHLIDIVEQLKIYENDLDPELLSAPQDVK] | |
50 μg | |
Primary | |
Mouse | |
Antibody | |
IgG |
ELISA, Immunohistochemistry (Paraffin) | |
1.0 mg/mL | |
Il21 | |
Interleukin-21, IL-21, Za11 | |
Goat | |
Antigen affinity chromatography | |
RUO | |
60505 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |