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CD18 Monoclonal Antibody (M18/2), FITC, Invitrogen™

Rat Monoclonal Antibody

Marke:  Invitrogen A15759

110.00 EUR gültig bis 2024-03-29
Benutzen Sie den Promotions-Code "21615" um Ihren Promotions-Preis zu erhalten.



Weitere Details : Netto-Gewicht : 0.00280kg

Artikelnummer. 15235844

  • 165.00 € / 0.10 Milligramm
Verfügbar ab: 23-04-2024
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Beschreibung

Beschreibung

CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling. CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits, and these integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the CD18 protein have been identified.
Spezifikation

Spezifikation

CD18
Monoclonal
0.5 mg/mL
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
P11835
Itgb2
Mouse CD18
100 μg
Primary
Mouse
Antibody
IgG2a
Flow Cytometry
M18/2
FITC
Itgb2
Cd18, LAD, LCAMB, Lfa1, MF17, Integrin beta-2 subunit, ITGB2, cluster designation 18
Rat
Purified
RUO
16414
4° C
Liquid
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote