anti-ITGAM/CD11b APC, Clone: ICRF44, Invitrogen™

Beschreibung

ITGAM/CD11b Monoclonal antibody A18613 from Invitrogen specifically detects ITGAM/CD11b in Human samples. It is validated for Flow Cytometry.

CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X, and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, and blood monocytes. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue.
Host Species: Mouse
Cross Reactivity: Human
Isotype: IgG1, κ
Clone: ICRF44
Immunogen: Rheumatoid synovial cells and human monocytes.
Formulation: 25 Tests Purified Antibody (0.2mg/ml) in PBS, with 0.1% gelatin and 0.09% sodium azide; pH7.2
Synonyms: CD11B, CR3A, MAC-1, MAC1A,mgC117044, MO1A, SLEB6, Integrin alpha M
Uniprot Accession: P11215
Entrez GeneID: 3684
Gene Symbol: ITGAM
This product detects ITGAM/CD11b in Human samples. This product has been successfully used in Flow Cytometry procedures. The immunogen is Rheumatoid synovial cells and human monocytes.