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MSH2 Mouse anti-Human, Clone: 25D12, Invitrogen™
Mouse Monoclonal Antibody
Marke: Invitrogen MA512224
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
MA5-12224 targets MSH2 (Mismatch Repair Protein 2) in IHC (P) applications and shows reactivity with Human samples. The MA5-12224 immunogen is recombit human MSH2 protein.
Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSbeta, which binds to insertion/deletion loops in DNA.Spezifikation
MSH2 | |
Monoclonal | |
Unconjugated | |
MSH2 | |
DNA mismatch repair protein Msh2,hMSH2, mutS protein homolog 2 | |
Mouse | |
500 μL | |
Primary | |
Human | |
Antibody | |
IgG1 κ |
Immunohistochemistry (Paraffin) | |
25D12 | |
tissue culture supernatant with 0.09% sodium azide | |
P43246 | |
MSH2 | |
Recombit human MSH2 protein | |
RUO | |
4436 | |
4° C | |
Liquid |