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MSK1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marke:  Invitrogen PA538369

Weitere Details : Netto-Gewicht : 0.00900kg

Artikelnummer. 15565291

  • 473.00 € / 100 Mikrogramm
Verfügbar ab: 07-05-2024
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Beschreibung

Beschreibung

MSK-1 is a mitogen and stress activated protein kinase-1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK-1can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG-14 in response to mitogen and stress. Similar to RSK, MSK-1 contains two kinase domains (N-term and a C-term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK-1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C-terminal kinase domain of MSK-1 which is essential for the catalytic activity of the N-terminal kinase domain.
Spezifikation

Spezifikation

MSK1
Polyclonal
Unconjugated
RPS6KA5
Ribosomal protein S6 kinase alpha-5, S6K-alpha-5, 90 kDa ribosomal protein S6 kinase 5, Nuclear mitogen- and stress-activated protein kinase 1, RSK-like protein kinase, RSKL, RPS6KA5, MSK1
Rabbit
Antigen affinity chromatography
RUO
73086, 9252
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
O75582, Q8C050
RPS6KA5
A synthetic non-phosphopeptide derived from human MSK1 around the phosphorylation site of Ser360(T-Y-SP-P-A)
100 μg
Primary
Human, Mouse, Non-human Primate
Antibody
IgG
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote