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p53 Mouse, Unlabeled, Clone: 80, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 610183

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15885309

  • 308.94 € / 1 Set
Verfügbar ab: 02-01-2023
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Beschreibung

Beschreibung

The p53 protein is critical to regulation of normal cell growth and is a suppressor of tumor cell proliferation. Inactivation of p53 by a number of mechanisms, such as missense mutations or interaction with oncogenic viral or cellular proteins, can result in tumor progression. Mutations and/or allelic loss of the p53 gene is associated with a wide variety of human tumors. Known to have a role in transcriptional regulation, p53 suppresses various promoters containing TATA elements in an apparently sequence-independent fashion. p53 also binds to DNA in a sequence-specific manner via recognition of a 20 bp consensus-binding site. This interaction stimulates the expression of genes downstream of the p53 binding site. A number of genes that contain p53-binding sites have been identified, including MDM2, GADD45, and muscle creatine kinase. It is thought that MDM2 is a feedback regulator of p53. In addition, a p53-inducible gene, Cip1, has been identified and shown to suppress tumor cell growth in culture.

Spezifikation

Spezifikation

p53
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
κ, IgG2a
50 μg
Cell Biology
Human, Canine
IgG2b κ
Western Blot
80
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.