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p53 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen 491031
Weitere Details : Netto-Gewicht : 0.10000kg
Beschreibung
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
p53 Polyclonal antibody specifically detects p53 in Human samples. It is validated for ChIP Assay, ChIP sequencing (ChIP-seq), ELISA, Western Blot.Spezifikation
| p53 | |
| Polyclonal | |
| Unconjugated | |
| Tp53 | |
| Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 7157 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ChIP Assay, ChIP sequencing (ChIP-seq), ELISA, Western Blot | |
| 2.73 mg/mL | |
| PBS with 0.05% ProClin 300, 0.05% sodium azide | |
| P04637 | |
| Tp53 | |
| Raised against the C-term of human p53. | |
| 50 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |