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PARP Mouse anti-Human, Unlabeled, Clone: 7D3-6, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 551024

Weitere Details : Netto-Gewicht : 0.02000kg

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Artikelnummer. 15886478

  • 329.46 € / 1 Stück
Verfügbar ab: 02-01-2023
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Beschreibung

Beschreibung

PARP [Poly(ADP-ribose) polymerase] is a 116kDa nuclear chromatin-associated enzyme that catalyzes the transfer of ADP-ribose units from NAD+ to a variety of nuclear proteins including topoisomerases, histones, and PARP itself. The catalytic activity of PARP is increased in nonapoptotic cells following DNA damage, and PARP is thought to play an important role in mediating the normal cellular response to DNA damage. Additionally, PARP is a target of the caspase protease activity associated with apoptosis. During apoptosis, PARP is cleaved from the 116kDa intact form into 85kDa and 25kDa fragments. This process separates the amino-terminal DNA-binding domain of the enzyme from the carboxy-terminal catalytic domain resulting in the loss of normal PARP function. Although the role of PARP in apoptosis remains to be elucidated, PARP cleavage is considered to be a marker of apoptosis.

Host Species: Mouse
Clone: 7D3-6
Isotype: IgG1
Species Reactivity: Human
Immunogen: Purified human PARP

Flow Cytometry, Immunoprecipitation, Western Blotting

Spezifikation

Spezifikation

PARP
Monoclonal
0.25mg/mL
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
7D3-6
Unconjugated
Purified human PARP
50 μg
Cell Biology
Human
IgG1
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.