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Phospho-Caspase 1 (Ser376) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA538565
Weitere Details : Netto-Gewicht : 0.00900kg
Beschreibung
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis (1). The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1/ICE (IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor.Spezifikation
Phospho-Caspase 1 (Ser376) | |
Polyclonal | |
Unconjugated | |
CASP1 | |
ICE, IL1BC, P45, CASP1 nirs variant 1, IL-1 beta-converting enzyme, IL1B-convertase, caspase 1, apoptosis-related cysteine peptidase interleukin 1, beta, convertase, caspase-1, interleukin 1, beta, convertase, interleukin 1-B converting enzyme | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
12362, 834 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P29466, P29452 | |
CASP1 | |
A synthetic phosphopeptide derived from human Caspase 1 around the phosphorylation site of Ser376 (R-F-SP-F-E) | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |