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Phospho-eIF4B (Ser422) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marke:  Invitrogen PA538362

Weitere Details : Netto-Gewicht : 0.00900kg

Artikelnummer. 15595281

  • 473.00 € / 100 Mikrogramm
Verfügbar ab: 06-05-2024
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Beschreibung

Beschreibung

eIF4B is a multidomain eukaryotic translation initiation factor with a range of activities. It contains one RRM (RNA recognition) domain, a consensus RNA-binding site (RNP-CS) near the N terminus, and a central domain rich in aspartic acid, arginine, tyrosine, and glycine (DRYG). The DRYG domain of eIF4B helps in self-association and interaction with the p170 subunit of eIF3. eIF4B binds to both mRNA and 18S ribosomal RNA and thus acts as a bridge between the mRNA and the 40S ribosomal subunit during translation initiation. The ATPase and RNA helicase activity of the DEAD box protein eIF4A is stimulated by eIF4B and thus functions in close association with eIF4F, a heterotrimeric protein that binds to mRNA cap structure and unwinds inhibitory secondary structure in the 5′ untranslated region of eucaryotic mRNAs in an ATP-dependent manner. Ubiquitous expression is seen in most tissues.
Spezifikation

Spezifikation

Phospho-eIF4B (Ser422)
Polyclonal
Unconjugated
EIF4B
Aryotic initiation factor 4B, Eukaryotic translation initiation factor 4B, hCG_2014609, eIF4B
Rabbit
Antigen affinity chromatography
RUO
1975, 300253, 75705
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
P23588, Q8BGD9
EIF4B
A synthetic phosphopeptide derived from human eIF4B around the phosphorylation site of Ser422 (T-G-SP-E-S)
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote