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Phospho-ELK1 (Thr417) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marke:  Invitrogen PA538131

Weitere Details : Netto-Gewicht : 0.00900kg

Artikelnummer. 15505061

  • 472.00 € / 100 Mikrogramm
Verfügbar ab: 06-05-2024
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Beschreibung

Beschreibung

ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.
Spezifikation

Spezifikation

Phospho-ELK1 (Thr417)
Polyclonal
Unconjugated
ELK1
ELK 1, Elk1, ELK1 member of ETS oncogene family, ELK1 protein, ELK1, ELK2 member of ETS oncogene family, ETS domain containing protein Elk 1, ETS domain containing protein Elk1, ETS domain protein Elk1, ETS domain-containing protein Elk-1, ETS like gene 1, Member of ETS oncogene family, Oncogene Elk1, Tyrosine kinase (ELK1) oncogene
Rabbit
Antigen affinity chromatography
RUO
13712, 2002, 314436
-20°C
Liquid
Immunohistochemistry (Paraffin), Immunoprecipitation
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
P19419, P41969, A4GTP4
ELK1
A synthetic phosphopeptide derived from human Elk-1 around the phosphorylation site of Thr417
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote