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Phospho-IR/IGF1R (Tyr1162, Tyr1163) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marke:  Invitrogen 44804G

Weitere Details : Netto-Gewicht : 0.50000kg

Artikelnummer. 10444693

  • 463.00 € / 1 Stück
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Beschreibung

Beschreibung

The antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody reactive with non-phosphorylated insulin/insulin-like growth factor-1 receptor (IR/IGF1R). The final product is generated by affinity chromatography using an IR/IGF1R-derived peptide that is phosphorylated at tyrosines 1162 and 1163 (tyrosines 1135 and 1136 for IGF1R. The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of IR/IGF1R that contains tyrosines 1162 and 1163 of the human insulin receptor (IR) as numbered according to Ebina, et al. (1150 and 1151 according to Ullrich et al.). The corresponding residues in the IGF1R are 1135 and 1136. The sequence is conserved in mouse and rat for both the IR and IGF1R. Although exhibiting a preference for IR/IGF1R, this antibody has been shown by both peptide competition and protein blotting to react with other dual-phosphotyrosine motifs from proteins such as c-Met and Shc. This antibody has been used in western blotting and previous lots of this antibody have been used in immunostaining. Positive controls used with this antibody in western analysis were Chinese hamster ovary cells transfected with a vector containing human insulin receptor (CHO-T) and stimulated with insulin, or 3T3-L1 cells stimulated with insulin.

Phospho-IR/IGF1R (Tyr1162, Tyr1163) Polyclonal antibody specifically detects Phospho-IR/IGF1R (Tyr1162, Tyr1163) in Human samples. It is validated for Immunocytochemistry, Immunohistochemistry, Western Blot.
Spezifikation

Spezifikation

Phospho-IR/IGF1R (Tyr1162, Tyr1163)
Polyclonal
Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
P06213, P08069
IGF1R, Insr
Synthetic phosphopeptide derived from the region of IR/IGF1R that contains tyrosines 1162 and 1163 of the human insulin receptor (IR)
100 μL
Primary
Human
Antibody
IgG
Immunocytochemistry, Immunohistochemistry, Western Blot
Unconjugated
Insr
4932439J01Rik; A330103N21Rik; CD220; CD221; D630014A15Rik; D930020L01; HHF5; hyft; IGF1 Receptor; IGF-1 receptor; IGF1 Receptor beta; Igf1r; IGF-1R; IGF1R beta; IGF-I receptor; IGF-I Receptor beta; IGFIR; IGFIRC; IGFR; Igfr1; Insr; insulin like growth factor 1 receptor; insulin receptor; insulin receptor precursor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; Insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; insulin-like growth factor 1 receptor beta subunit; insulin-like growth factor I receptor; insulin-like growth factor receptor 1; insulin-like growth factor receptor type 1; insulin-like growth factor-I receptor; insulin-like growth factor-I receptor precursor; IR; IR-A; IR-B; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2
Rabbit
Antigen affinity chromatography
RUO
3480, 3643
-20°C
Liquid
Produktvorschläge

Produktvorschläge

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Dokumentation

Dokumentation

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