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Phospho-IRAK1 (Thr100) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marke:  Invitrogen PA538631

Weitere Details : Netto-Gewicht : 0.00900kg

Artikelnummer. 15515551

  • 472.00 € / 100 Mikrogramm
Verfügbar ab: 06-05-2024
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Beschreibung

Beschreibung

Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. IRAK is associated with Toll-like receptor (TLR) and IL-1R signaling pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK′s association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
Spezifikation

Spezifikation

Phospho-IRAK1 (Thr100)
Polyclonal
Unconjugated
IRAK1
IL-1 Receceptor Associated Kinase, Interleukin-1 receptor-associated kinase 1, mPLK, IRAK, pelle, Pelle homolog, Pelle
Rabbit
Antigen affinity chromatography
RUO
16179, 3654
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
P51617, Q62406
IRAK1
A synthetic phosphopeptide derived from human IRAK1 around the phosphorylation site of Thr100 (I-I-TP-A-W)
100 μg
Primary
Human, Mouse
Antibody
IgG
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote