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Phospho-MSK1 (Ser376) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marke:  Invitrogen PA538141

Weitere Details : Netto-Gewicht : 0.00900kg

Artikelnummer. 15505071

  • 472.00 € / 100 Mikrogramm
Verfügbar ab: 06-05-2024
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Beschreibung

Beschreibung

MSK-1 is a mitogen and stress activated protein kinase-1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK-1can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG-14 in response to mitogen and stress. Similar to RSK, MSK-1 contains two kinase domains (N-term and a C-term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK-1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C-terminal kinase domain of MSK-1 which is essential for the catalytic activity of the N-terminal kinase domain.
Spezifikation

Spezifikation

Phospho-MSK1 (Ser376)
Polyclonal
Unconjugated
RPS6KA5
90 kDa ribosomal protein S6 kinase, , polypeptide 5, KS6A5, MSPK1, Nuclear mitogen- and stress-activated protein kinase-1, RLPK, RPS6KA5, kinase MSK1, ribosomal protein S6 kinase, polypeptide V
Rabbit
Antigen affinity chromatography
RUO
314384, 73086, 9252
-20°C
Liquid
Western Blot
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
O75582, Q8C050
RPS6KA5
A synthetic phosphopeptide derived from human MSK1 around the phosphorylation site of Ser376 (G-Y-SP-F-V)
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote