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Phospho-PLK1 (Thr210) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA538320
Weitere Details : Netto-Gewicht : 0.00900kg
Beschreibung
Considerable evidence indicates that a Polo-Like Kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.Spezifikation
| Phospho-PLK1 (Thr210) | |
| Polyclonal | |
| Unconjugated | |
| PLK1 | |
| Serine/threonine-protein kinase PLK1, Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13, PLK1, PLK | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 18817, 25515, 5347 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 1 mg/mL | |
| Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P53350, Q07832, Q62673 | |
| PLK1 | |
| A synthetic phosphopeptide derived from human PLK1 around the phosphorylation site of Thr210 (K-K-TP-L-C) | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |