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PKCι Mouse, Unlabeled, Clone: 23, BD

Mouse Monoclonal Antibody

251.00 € - 434.00 €

Spezifikation

Antigen PKCι
Isotyp IgG2b
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Rezeptur Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Konjugat Unconjugated
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15805309
Unterlagen ansehen
BD Biosciences
610175
50μg 251.00 €
1 Set Alternative Produkte anzeigen
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Verfügbar ab
10-11-2020
Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!
15815309
Unterlagen ansehen
BD Biosciences
610176
150μg 434.00 €
1 Set Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab
16-11-2020
Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!
Beschreibung

Beschreibung

The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. These proteins are products of multiple genes and alternative splicing. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions(V). The N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts with the PKC activators Ca2+, phospholipid, diacylglycerol, or phorbol ester. However, the novel PKC (nPKC) subfamily members (δ, ε, η and θ isoforms) and the atypical PKC (aPKC) subfamily members (ζ, ι and γ isoforms) are Ca2+ independent and lack the C2 domain. The aPKC members are unique in that their activity is independent of diacylglycerols and phorbol esters. They also lack one repeat of the cysteine-rich sequences that are conserved in cPKC and nPKC. The C-terminal region of PKC contains the catalytic domain. The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters, and growth factors. PKCι was isolated from a human kidney cDNA library. It is highly expressed in brain and lung, but it is also seen in many other tissues at lower levels. PKCι shows the most similarity to PKCζ , 72% overall identity. These two enzymes share a highly conserved pseudosubstrate sequence, the absence of a Ca2+-binding region, and the presence of only one zinc finger-like domain. It is thought that PKC? has a role in the secretory response to nutrients.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Spezifikation

Spezifikation

PKCι
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG2b
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
23
250μg/mL

For Research Use Only.