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PKCα Mouse, Unlabeled, Clone: 3/PKC, BD
Mouse Monoclonal Antibody
330.00 € - 650.00 €
Spezifikation
Antigen | PKCα |
---|---|
Klon | 3/PKC |
Konzentration | 250μg/mL |
Anwendungen | Western Blot |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15895259
|
BD Biosciences
610107 |
50 μg |
330.00 €
1 Set |
Verfügbar ab: 14-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
15805269
|
BD Biosciences
610108 |
150 μg |
650.00 €
1 Set |
Verfügbar ab: 16-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. These proteins are products of multiple genes and alternative splicing. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts with PKC activators Ca2+;, phospholipid, diacylglycerol, or phorbol ester. However, the novel PKC (nPKC) subfamily members ( δ, ε, η, and θ isoforms) and the atypical PKC (aPKC) subfamily members (ζ, ι, and λ isoforms) are Ca2+; independent and lack the C2 domain. The aPKC members are unique in that their activity is
independent of diacylglycerols and phorbol esters. They also lack one repeat of the cysteine-rich sequences that are conserved in cPKC and nPKC. The C-terminal region of PKC contains the catalytic domain. The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters and growth factors. Overexpression of PKCα has been reported to lead to an enhanced growth rate and induces the phosphorylation of two cellular proteins of 52kDa and 90kDa.
Host Species: Mouse
Clone: 3
Isotype: IgG2b
Species Reactivity: Rat
Immunogen: Human PKCα aa. 270-427
Formula Weight [Chemical]: 82kDa
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Spezifikation
PKCα | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG2b κ | |
Affinity Purified | |
Protein Kinase C α, PKC-α, PKC-A, PKCA, PRKCA |
3/PKC | |
Western Blot | |
Unconjugated | |
RUO | |
Canine, Chicken, Frog, Human, Mouse, Rat | |
Human PKCα aa. 270-427 | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.