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PKCλ Mouse, Unlabeled, Clone: 41, BD

Mouse Monoclonal Antibody

251.00 € - 474.00 €

Spezifikation

Antigen PKCλ
Isotyp IgG1
Immunogen Human PKCγ aa. 397-558
Rezeptur Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Konjugat Unconjugated
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15895329
Unterlagen ansehen
BD Biosciences
610207
50μg
251.00 €
1 Set
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Verfügbar ab
20-11-2020
Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!
15805339
Unterlagen ansehen
BD Biosciences
610208
150μg
474.00 €
1 Set
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab
20-11-2020
Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!
Beschreibung

Beschreibung

The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. These proteins are products of multiple genes and alternative splicing. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts with the PKC activators Ca2+, phospholipid, diacylglycerol, or phorbol ester. However, the novel PKC (nPKC) subfamily members ( δ, ε, η, and θ isoforms) and the atypical PKC (aPKC) subfamily members (ζ, ι, and λ isoforms) are Ca2+ independent and lack the C2 domain. The aPKC members are unique in that their activity is independent of diacylglycerols and phorbol esters. They also lack one repeat of the cysteine-rich sequences that are conserved in cPKC and nPKC. The C-terminal region of PKC contains the catalytic domain. The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters, and growth factors. PKC? shows the highest degree of amino acid homology with PKCζ (72%) and PKCλ mRNA is expressed in a variety of cells and tissues. The PKCλ protein kinase is capable of autophosphorylation and can be activated by phosphatidylserine, but not by other PKC activators such as diacylglycerols, Ca2+, or phorbol esters.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Spezifikation

Spezifikation

PKCλ
Human PKCγ aa. 397-558
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
41
250μg/mL
Sicherheitsdatenblatt (SDS)

For Research Use Only.