S100B Polyclonal Antibody, Invitrogen™

Beschreibung

PA1-31162 detects S100 beta from mouse and human samples. PA1-31162 has been successfully used in immunohistochemistry, immunoprecipitation, and Western blot applications. Positive control of rat brain tissue lysate suggested. The PA1-31162 immunogen is full length native protein homodimer (purified) (Human). Store at 4°C short term. For extended storage, aliquot and store at -20°C or below. Avoid freeze/thaw cycles.

S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several diseases, including Alzheimer′s disease, Down′s syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.