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Syk Mouse anti-Human, Clone: 12E3, Invitrogen™
Mouse Monoclonal Antibody
Marke: Invitrogen MA517207
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
A suggested positive control for this product is THP-1 cells.
Syk, Spleen tyrosine kinase, is expressed in a wide range of hematopoietic and non-hematopoietic cells and plays a key role in adaptive immune system, which is the immunoreceptor (B cell receptor and Fc-receptors) signaling pathways including Fcgamma receptor-mediated phagocytosis. In hematopoietic cells such as B and T lymphocytes, natural killer cells, mast cells, macrophages and platelets, Syk is involved in the proximal signaling downstream of activated immunoreceptors (e.g. BCR, TCR, Fc receptors) containing immunoreceptor tyrosine-based activation motifs (ITAMs) to which it binds using its tandem SH2 domains. Activated and autophosphorylated Syk then phosphorylates its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.Spezifikation
SYK | |
Monoclonal | |
Unconjugated | |
SYK | |
Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-syk | |
Mouse | |
Ammonium sulfate precipitation | |
RUO | |
6850 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot | |
12E3 | |
HEPES with 0.01% BSA, 0.15M NaCl, 50% glycerol and 0.03% sodium azide | |
P43405 | |
SYK | |
Synthetic peptide | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG2b |