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AT 101, Tocris Bioscience™

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

Marke:  Tocris (Bio-Techne) 336750

Weitere Details : Netto-Gewicht : 0.01000kg

Menge. 50mg

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Artikelnummer. 13412904

  • 830.68 € / 50 Milligramm


Voraussichtlicher Liefertermin 27-06-2019
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Beschreibung

Beschreibung

R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.
Spezifikation

Chemische Identifikatoren

90141-22-3
518.562
gossypol, --gossypol, +-gossypol, pogosin, tash 1, racemic-gossypol, r---gossypol, r-gossypol, +--gossypol, +/--gossypol
CHEBI:28584
CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C
C30H30O8
QBKSWRVVCFFDOT-UHFFFAOYSA-N
3503
7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde

Spezifikation

AT 101
90141-22-3
gossypol, --gossypol, +-gossypol, pogosin, tash 1, racemic-gossypol, r---gossypol, r-gossypol, +--gossypol, +/--gossypol
CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C
518.562
CHEBI:28584
>98%
50mg
C30H30O8
QBKSWRVVCFFDOT-UHFFFAOYSA-N
7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde
3503
518.56
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