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Invitrogen™ Bcl-B Polyclonal Antibody
Beschreibung
Recommended positive controls: A431, H1299, HeLa, HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway.
Spezifikation
Spezifikation
| Antigen | Bcl-B |
| Anwendungen | Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry |
| Klassifikation | Polyclonal |
| Konzentration | 0.51 mg/mL |
| Konjugat | Unconjugated |
| Zusammensetzung | 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 |
| Gen | BCL2L10 |
| Gen-Zugriffsnummer | Q9HD36 |
| Gen-Alias | AA420380; anti-apoptotic protein Boo; Anti-apoptotic protein NrH; apoptosis regulator Bcl-B; AU023065; Bcl-2 homolog Diva; BCL2 like 10; BCL2L10; bcl2-L-10; Bcl2-like 10; BCL2-like 10 (apoptosis facilitator); bcl-2-like protein 10; BCLB; BCL-B; Boo; C85687; death inducer binding to vBcl-2 and Apaf-1; Diva |
| Gensymbole | BCL2L10 |
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