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ACROBiosystems Biotinylated Human CD20 / MS4A1 Full Length Protein, His, Avitag™ (Nanodisc) (HEK293)

Biotinylated Protein

1916.71 € - 5750.12 €

Spezifikation

Quelle Biotinylated Human CD20 Full Length, His,Avitag (CD0-H82E3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Pro 297 (Accession # P11836-1).
Gebräuchliche Bezeichnung CD20
Expressionssystem HEK293
Format Powder
Konjugat Precision Avi
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
17116111
Unterlagen ansehen
ACROBiosystems
CD0-H82E3-100UG
100 µg
5750.12 €
100 Mikrogramm
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Voraussichtliches Versanddatum: 02-11-2021
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17126111
Unterlagen ansehen
ACROBiosystems
CD0-H82E3-20UG
20 µg
1916.71 €
20 Mikrogramm
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»
Voraussichtliches Versanddatum: 02-11-2021
Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!
Beschreibung

Beschreibung

B-lymphocyte antigen CD20 is also known as B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1 and MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells. It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. The protein has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that it acts as a calcium channel in the cell membrane. CD20 / MS4A1 is the target of the monoclonal antibodies (mAb) rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen.

Nanodiscs are a new class of model membranes that are being used to solubilize and study a range of integral membrane proteins (mp,full length CD20) and membrane-associated proteins. The Nanodisc bilayer is bounded by a membrane scaffold protein (MSP1D1)
Spezifikation

Spezifikation

Biotinylated Human CD20 Full Length, His,Avitag (CD0-H82E3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Pro 297 (Accession # P11836-1).
HEK293
Precision Avi
-20°C
CD20
Powder
MABSol™ Biotin Labeled Proteins
Sicherheitsdatenblatt (SDS)
Produktzertifizierungen