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ACROBiosystems Biotinylated Human TIM-3 / HAVCR2 Protein, Avitag™,His Tag
Biotinylated Protein
423.38 € - 1862.87 €
Spezifikation
Zugriffsnummer | NP_116171.3 |
---|---|
Molekulargewicht | 23.1 kDa |
Quelle | Biotinylated Human TIM-3, Avitag,His Tag (TM3-H82E7) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 200 (Accession # Q8TDQ0-1). |
Immunogen | Ser 22 - Arg 200 |
Lagerungsbedingungen | -20°C |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15887797
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ACROBiosystems
TM3-H82E7-25UG |
25 μg |
423.38 €
25 Mikrogramm |
Verfügbar ab: 26-04-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
15877797
|
ACROBiosystems
TM3-H82E7-200UG |
200 μg |
1862.87 €
200 Mikrogramm |
Verfügbar ab: 26-04-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 23.1 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_116171.3 | |
Biotinylated Human TIM-3, Avitag,His Tag (TM3-H82E7) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 200 (Accession # Q8TDQ0-1). | |
-20°C | |
TIM-3 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |
23.1 kDa | |
Ser 22 - Arg 200 | |
HAVCR2,TIM3,TIMD3,FLJ14428,KIM3 | |
Precision Avi | |
His Tag and Avi Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |